Lymph nodes play a vital role in the immune system of our body, by way of protecting from various infectious particles. These lymph nodes get swollen and become painful due to invasion into the body by bacteria, viruses, parasitic infections, fungi, certain autoimmune disorders, tumors etc. Any swollen lymph node that does not subside within 3-4 weeks should raise an alarm and it becomes necessary to get it evaluated thoroughly for its cause.
The most common type of psoriasis is called plaque psoriasis. It causes a thick, patchy, red rash with silvery, white scales. It can appear anywhere but most often occurs on the scalp, elbows, knees, and lower back. The condition is not contagious, and it's fairly common, affecting 2% to 3% of Americans. Psoriasis is more common in adults than children.
"What we saw with two vaccines, given four weeks apart, was the death of bad T-cells," said study author Dr. Denise Faustman, director of the immunobiology laboratory at Massachusetts GeneralHospital in Boston. "We also saw that regulatory T-cells came on -- these are the good-guy T-cells. And the pancreas went on briefly, and this was in people who were 15 years out from their type 1 diagnosis."
Anne McGettrick co-led the study that identified TMED7. She likens the immune system to an orchestra with many different sections, and TMED7 to one of the instruments. It is the first member of a family of proteins to be identified as an important regulator of the immune system.
“Why that’s exciting to us is because the more we can tweak just small aspects of our immune system, and the more we understand about how each bit works, the more likely we are to understand what’s going wrong in diseases - why some people get different symptoms - and that when their immune system goes wrong we can work out which pathways are going wrong,” McGettrick said.
Fleishmann explained that while people with the disease have benefitted from the discovery of "biologic" drugs such as Humira (adalimumab), Enbrel (etanercept) and Remicade (infliximab), many patients don't find relief from these medications. Biologic products are large proteins that are available only by injection or intravenous administration. The hope, he said, is that JAK inhibitors will help improve the lives of those not getting enough relief from other medications.